Scutellaria baicalensis Georgi, or Chinese skullcap, has been widely used as a medicinal plant in China for thousands of years, where the preparation from its roots is called Huang-Qin. It has been applied in the treatment of diarrhea, dysentery, hypertension, hemorrhaging, insomnia, inflammation and respiratory infections. Flavones such as baicalin, wogonoside and their aglycones baicalein wogonin are the major bioactive compounds extracted from the root of S. baicalensis. These flavones have been reported to have various pharmacological functions, including anti-cancer, hepatoprotection, antibacterial and antiviral, antioxidant, anticonvulsant and neuroprotective effects. In this review, we focus on clinical applications and the pharmacological properties of the medicinal plant and the flavones extracted from it. We also describe biotechnological and metabolic methods that have been used to elucidate the biosynthetic pathways of the bioactive compounds in Scutellaria.
Baicalin, a flavonoid Kampo compound purified from the dry roots of Radix Scutellariae, has been shown to possess the potential to be used as a novel drug in the treatment of pulmonary arterial hypertension (PAH) pathology. PAH is a cardiovascular disease characterized by enhanced pulmonary artery smooth muscle cell (SMC) proliferation and suppressed apoptosis.
Radix Scutellariae extract improves the immune system, increases energy, products the liver, and strengthens bones. Furthermore it improves phagocytes and promotes blood circulation.Especially effective in lowering blood pressure of patients with hypertension.
1. It is used to treat respiratory and gastrointestinal infections, allergic rhinitis, jaundice, viral hepatitis, nephritis, pelvic inflammation, sores or swelling, and fever.
2. It is also used orally for scarlet fever, headache, irritability, red eyes, flushed face, seizures, epilepsy, hysteria, nervous tension, and a bitter taste in the mouth.