40% Silymarin Milk Thistle Extract: Trusted, High-Yield Ingredient For Premium Liver Care Solutions

Milk Thistle Extract

Latin Name                     Silybum marianum (L.) Gaerth

Family                          Compositae

Part of the Plant Used             Seed

Product Introduction 

Milk Thistle Extract | Standardized Silymarin Complex

Originating in Europe, milk thistle's bioactive flavonolignan complex silymarin is recognized for supporting liver vitality. Comprising silybin (A/B), isosilybin, silychristin, and silydianin, modern research demonstrates:

• Cellular Defense: Stabilizes hepatocyte membranes against toxins (Front. Pharmacol., 2023)

• Antioxidant Activation: Enhances glutathione synthesis via Nrf2 pathway (Oxid. Med. Cell. Longev., 2022)

• Metabolic Modulation: Regulates inflammatory mediators (TNF-α, IL-6) in preclinical models

Sunfull's Innovation:

• Water-Soluble Technology: Patented formulation overcoming poor aqueous solubility (20%-40% silymarin)

• Global Compliance: Marketed in EU/Asia with GRAS & Novel Food certifications

Product Specifications

Evidence-Based Functions

✓ Hepatocyte Integrity Support

• Promotes liver cell regeneration mechanisms (Int. J. Mol. Sci., 2021)
  ✓ Toxin Challenge Response

• Modulates xenobiotic transporters (P-glycoprotein)
  ✓ Oxidative Stress Management

• Reduces lipid peroxidation 
  ✓ Inflammatory Pathway Modulation

• Inhibits NF-κB signaling in hepatic tissues

Physiological Functions 

Evidence-Based Actions

✓ Liver Health Support

• Modulates biomarkers in hepatic metabolic stress (Int. J. Mol. Sci., 2023)
  ✓ Toxin Challenge Response

• Enhances detoxification pathways against heavy metals & ethanol (Front. Pharmacol., 2022)
  ✓ Bile Flow Regulation

• Promotes healthy cholesterol metabolism & bile secretion
  ✓ Cellular Antioxidant Defense

• Reduces lipid peroxidation

Traditional Applications (Documented Use)

• Menstrual cycle comfort • Skin vitality support • Venous circulation

Toxicity Profile (Science-Verified)

Acute Safety:

• Oral LD₅₀ >20 g/kg (mice) & >1 g/kg (dogs) - Practically non-toxic (OECD 423)

• Intravenous LD₅₀: 140-400 mg/kg across species

Chronic Safety:

• No observed adverse effects at 1,000 mg/kg/day (90-day rat study)

• No embryotoxicity (EFSA Panel 2021)

Applications

• Nutraceuticals: Liver support capsules, detox formulations

• Functional Foods: Antioxidant beverages, lipid-balancing blends

• Cosmeceuticals: Redness-reduction serums (via anti-inflammatory action)

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