98% EGCG Green Tea Extract Powder Polyphenols Epigallocatechin Gallate

Molecular formula: C₂₂H₁₈O₁₁
Molecular weight: 458.38
Product Spec.: 98%
Molecular Structure

 
 
Product Introduction
EGCG is a catechin peculiar to tea, with the highest amount, accounting for 40% to 50% of tea polyphenol products. It is an ester of 2-continuous phenol benzopyran and gallic acid. It has the versatility of phenolic antioxidants and has many properties
superior to other catechins due to its structure with 6 ortho-phenolic hydroxyl groups.

Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited. In this study, we determined the cancer chemopreventive potentials of 10 representative polyphenols (caffeic acid, CA; gallic acid, GA; catechin, C; epicatechin, EC; gallocatechin, GC; catechin gallate, CG; gallocatechin gallate, GCG; epicatechin gallate, ECG; epigallocatechin, EGC; and epigallocatechin gallate, EGCG), and explored their structure-activity relationship. The effect of the 10 polyphenol compounds on the proliferation of HCT-116 and SW-480 human colorectal cancer cells was evaluated using an MTS assay. Cell cycle distribution and apoptotic effects were analyzed by flow cytometry after staining with propidium iodide (PI)/RNase or annexin V/PI. Among the 10 polyphenols, EGCG showed the most potent antiproliferative effects, and significantly induced cell cycle arrest in the G1 phase and cell apoptosis. When the relationship between chemical structure and anticancer activity was examined, C and EC did not show antiproliferative effects, and GA showed some antiproliferative effects. When C and EC esterified with GA to produce CG and ECG, the antiproliferative effects were increased significantly. A similar relationship was found between EGC and EGCG. The gallic acid group significantly enhanced catechin’s anticancer potential. This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents.

 

 
Physiological Functions
1. Fights oxidative stress / inflammation
2. Supports heart health
3. Helps protect the brain
4. Enhancing immune function
5. Weight loss
 
 
Applications
1. Pharmaceutical stuff
2. Health food
3. Cosmetics additives