Ecdysone (20-Hydroxyecdysone) of Hunan Sunfull Bio-tech Co., Ltd.
Botanical Resource: Cyanotis arachnoidea C.B.Clarke
Molecular formula: C27H44O7
Molecular weight: 480.64
CAS No.: 5289-74-7
Beta-20-Hydroxyecdysone 90%/95% by HPLC
Beta-20-Hydroxyecdysone 90%/95% by UV
Ecdysone (20-Hydroxyecdysone or 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. It is therefore one of the most common moulting hormones in insects, crabs, etc. It is also a phytoecdysteroid produced by various plants, where its purpose is presumably to disrupt the development and reproduction of insect pests. In arthropods, 20E acts through the ecdysone receptor. Although mammals lack this receptor, Ecdysone does appear to affect mammalian (including human) physiology, but there is disagreement over the details of its effects. Ecdysone is an ingredient of some preparations that aim to enhance physical performance. Generally speaking, for human body, promoting protein synthesis, eliminating cholesterol, regulating blood glucose and lipid, anti-arrhythmia, anti-fatigue, treatment of rheumatoid arthritis.
Use as supplement
20-Hydroxyecdysone and other ecdysteroids are marketed as ingredients in nutritional supplements for various sports, particularly bodybuilding. The evidence to support such use, however, is limited. A comprehensive study, designed to find any strength or athletic improvement from 20-hydroxyecdysone was published in 2006. The study looked for improvement in actual exercises performed and tested for improvements/increases in chemical indicators such as body composition and free/available. The study concluded that supplementation with up to 200 mg per day had no effect.
Use as research tool
20-Hydroxyecdysone and other ecdysteroids are used in biochemistry research as inducers in transgenic animals, whereby a new gene is introduced into an animal so that its expression is under the control of an introduced ecdysone receptor. Adding or removing ecdysteroids from the animal's diet then gives a convenient way to turn the inserted gene on or off (see ecdysone receptor). At usual doses, 20-hydroxyecdysone appears to have little or no effect on animals that do not have extra genes inserted; it also has high bioavailability when taken orally, so it is useful for determining whether the transgene has been taken up effectively. For uses in gene therapy, it may be necessary to investigate more thoroughly the natural sources of ecdysteroids in humans (which appear to include dietary phytoecdysteroids, gut flora, helminth infections, and other diseases).
There is some in vitro evidence to show that 20-hydroxyecdysone has effects on some kinds of blood cells such as lymphocytes and neutrophils, and may act as an immunomodulator. This would explain the mechanism behind Helminthic therapy due to the production of ecdysteroids by helminths, as mentioned above.
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HPLC Chromatogram of 95% Beta-20-Hydroxyecdysone
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